Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

Sacha Inchi (Plukenetia Volubilis L.), SI, is the oleaginous plant of the Euphorbiaceous family originally cultivated in the Amazonian forest. It is traditionally appreciated and consumed as the healthful food. In vivo, in vitro and clinical studies have suggested the beneficial effects of SI for a variety of neuroprotection, dermatology, antidyslipidaemic, antioxidant and anti-inflammatory, antiproliferative and antitumor modulation activities. Many of these potential impacts are related to its bioactive compounds, particularly essential fatty acids, proteins and phytochemicals. However, there are some scientific evidences underlying the risk of toxicity associated with the high doses of SI seed oils. With the aforementioned, this review outlines a narrative review of SI, including its ethnobotanical components, phytochemistry profile, organoleptic and sensory evaluations. The essential development of its latest applications in the field of medicine, pharmacology, safety and toxicological issues, are laconically demonstrated. Moreover, the underlying challenges and upcoming prospective for the integration of SI use are detailed.