Fulltext

Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia

Harapan H 1 , Fathima R 1 , Kusuma HI 1 , Anwar S 2 , Nalapraya WY 3 , Wibowo A 4 Show all authors , Wati KDK 5 , Medina A 1 , Defrita AH 6 , Astri Y 7 , Prasetyowati A 8 , Nurfarahin N 1 , Khusna A 1 , Oktariana S 1 , Anwar S 9 , Yussar MO 10 , Khotimah S 11 , Nainggolan BWM 12 , Badri PRA 13 , Argarini R 14 , Winardi W 15 , Indah R 16 , Sallam M 17 , Rajamoorthy Y 18 , Wagner AL 19 , Mudatsir M 1

Affiliations 

  • 1 Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • 2 Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • 3 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Islam Bandung, Bandung 40116, Indonesia
  • 4 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lampung, Bandar Lampung 35145, Indonesia
  • 5 Department of Child Health, Faculty of Medicine, Universitas Udayana, Denpasar 80234, Indonesia
  • 6 Faculty of Medicine, Universitas Jambi, Jambi 36373, Indonesia
  • 7 Neurology Department, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang 30263, Indonesia
  • 8 Mungkid Community Health Center, Magelang 56512, Indonesia
  • 9 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Tadulako University, Palu 94148, Indonesia
  • 10 Faculty of Public Health, University Muhammadiyah Aceh, Banda Aceh 23245, Indonesia
  • 11 Biochemistry Laboratory, Medical Faculty of Mulawarman University, Samarinda 75119, Indonesia
  • 12 Undergraduate Program in Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia
  • 13 Public Health Department, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang 30263, Indonesia
  • 14 Department of Medical Physiology and Biochemistry, Universitas Airlangga, Surabaya 60132, Indonesia
  • 15 Department of Pulmonology and Respiratory Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • 16 Medical Education Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • 17 Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan
  • 18 Department of Economics, Faculty of Accountancy and Management, Universiti Tunku Abdul Rahman, Kuala Lumpur 43200, Malaysia
  • 19 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Vaccines (Basel), 2022 Nov 22;10(12).
PMID: 36560390 DOI: 10.3390/vaccines10121981

Abstract

Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications