Empowering quality data - the Gordian knot of bringing real innovation into healthcare system

Horgan D 1 , Hamdi Y 2 , Lal JA 3 , Nyawira T 4 , Meyer S 5 , Kondji D 6 Show all authors , Francisco NM 7 , De Guzman R 8 , Paul A 9 , Nallamalla KR 10 , Park WY 11 , Triapthi V 3 , Tripathi R 12 , Johns A 13 , Singh MP 14 , Phipps ME 15 , Dube F 16 , Abu Rasheed HM 17 , Kozaric M 1 , Pinto JA 18 , Stefani SD 19 , Aponte Rueda ME 20 , Alarcon RF 21 , Barrera-Saldana HA 22

Affiliations 

  • 1 European Alliance for Personalised Medicine, Brussels, Belgium
  • 2 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia
  • 3 Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering Sam Higginbottom University of Agriculture, Technology and Sciences Prayagraj, India
  • 4 National Commission for Science, Technology and Innovation in Kenya (NACOSTI), Nairobi Kenya, Kenya
  • 5 Cancer Alliance, Cape Town, South Africa
  • 6 Health & Development Communication, Building Capacity for Better Health in Africa Building Capacities for Better Health in AFRICA, Yaounde, Cameroun
  • 7 Grupo de Investigação Microbiana e Imunológica, Instituto Nacional de Investigação em Saúde (National Institute for Health Research), Luanda, Angola
  • 8 Oncology and Pain Management Section, Manila Central University-Filemon D. Tanchoco Medical Foundation Hospital, Caloocan City, Philippines
  • 9 Department of Mathematics and Statistics, Faculty of Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India
  • 10 ACCESS Health India, Hyderabad, India
  • 11 Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea
  • 12 Department Health Govt of India, Ministry of labor, New Delhi, India
  • 13 Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, Sydney, Australia
  • 14 Center of Biotechnology, University of Allahabad, Allahabad, India
  • 15 Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia
  • 16 Astra Zeneca, Concord Pike, Wilmington, DE, USA
  • 17 Qatar Cancer Society, Doha, Qatar
  • 18 Center for Basic and Translational Research, Auna Ideas, Lima, Peru
  • 19 UNIMED RS, Porto Alegre, Brazil
  • 20 Venezuelan Breast Cancer Research and Education Foundation, Caracas, Venezuela
  • 21 Centro de Genética y Biología Molecular, Universidad de San Martín de Porres, Lima, Perú
  • 22 Innbiogem SC/Vitagenesis SA at National Laboratory for Services of Research, Development, and Innovation for the Pharma and Biotech Industries (LANSEIDI) of CONACyT Vitaxentrum Group, Monterrey, Mexico
Diagnosis (Berl), 2023 May 01;10(2):140-157.
PMID: 36548810 DOI: 10.1515/dx-2022-0115

Abstract

OBJECTIVES: The introduction of Personalised Medicine (PM) into healthcare systems could benefit from a clearer understanding of the distinct national and regional frameworks around the world. Recent engagement by international regulators on maximising the use of real-world evidence (RWE) has highlighted the scope for improving the exploitation of the treasure-trove of health data that is currently largely neglected in many countries. The European Alliance for Personalised Medicine (EAPM) led an international study aimed at identifying the current status of conditions.

METHODS: A literature review examined how far such frameworks exist, with a view to identifying conducive factors - and crucial gaps. This extensive review of key factors across 22 countries and 5 regions revealed a wide variety of attitudes, approaches, provisions and conditions, and permitted the construction of a comprehensive overview of the current status of PM. Based on seven key pillars identified from the literature review and expert panels, the data was quantified, and on the basis of further analysis, an index was developed to allow comparison country by country and region by region.

RESULTS: The results show that United States of America is leading according to overall outcome whereas Kenya scored the least in the overall outcome.

CONCLUSIONS: Still, common approaches exist that could help accelerate take-up of opportunities even in the less prosperous parts of the world.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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