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Pulmonary dysfunction in overweight and obese children with obstructive sleep apnoea

Kasim AS 1 , Golbabapour S 2 , Zaini AA 1 , Peng EK 1 , Jalaludin MY 1 , Nathan AM 1 Show all authors , Chinna K 3 , Thavagnanam S 1

Affiliations 

  • 1 Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
  • 3 UCSI university Kuala Lumpur, Kuala Lumpur, Malaysia
Endocrinol Diabetes Metab, 2023 Apr 06.
PMID: 37021461 DOI: 10.1002/edm2.417

Abstract

INTRODUCTION: Overweight and obese children are at risk of obstructive sleep apnoea (OSA) and abnormal pulmonary function (PF).

AIM: Investigate the relationship between body mass index (BMI), OSA on PF in children.

MATERIALS & METHOD: Seventy-four children were recruited. Mixed obstructive apnoea-hypopnea index (MOAHI), BMI, oxygen saturation (SpO2 ), forced expiratory volume one second (FEV1 ), forced vital capacity (FVC) and fractionated exhaled nitric oxide (FeNO) were measured.

RESULTS: Twenty-four and thirty children had mild OSA and moderate-to-severe OSA respectively. BMI correlated negatively with SpO2 nadir (r = -.363, p = .001). FVC, FEV1 and nadir SpO2 values decreased with OSA severity (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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