Affiliations 

  • 1 Ali-Ul-Murtaza, Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences Multan 60000, Punjab, Pakistan
  • 2 Key Laboratory of Glycoscience and Glycotechnology of Shandong Province Qingdao 266003, Shandong, China
  • 3 Department of Pharmacology and Physiology, MNS University of Agriculture Multan 60000, Punjab, Pakistan
  • 4 Faculty of Veterinary & Animal Sciences, MNS University of Agriculture Multan 60000, Punjab, Pakistan
  • 5 College of Life Science, Hebei Normal University Shijiazhuang 050024, Hebei, China
  • 6 BioInspired Device and Tissue Engineering Research Group (BioInspira), Department of Biomedical Engineering and Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia Johor Bahru 81310, Johor, Malaysia
  • 7 Faculty of Medicine, AIMST University Bedong 08100, Kedah, Malaysia
Am J Transl Res, 2023;15(7):4533-4543.
PMID: 37560231

Abstract

OBJECTIVE: Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. Mangifera indica has been used traditionally to treat a variety of ailments in animals and human, but little is defined about its biological or pharmacological effects. Therefore, the objective of the present study was to evaluate phytochemical, antioxidant, antipyretic and anti-inflammatory activities of aqueous-methanolic leaf extract of M. indica.

METHODS: To investigate the possible impact of aqueous-methanolic leaf extract of M. indica on oxidative stress, inflammation, and pyrexia, we used a combined in vitro and in vivo series of experiments on laboratory animals.

RESULTS: Results revealed significant antioxidant potential in 2,2-diphenylpicrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assay, while significant but dose dependent antipyretic potential was documented in typhoid-paratyphoid A and B (TAB) vaccine and prostaglandin E (PGE) induced pyrexia models. Significant anti-inflammatory effects were observed in both acute and chronic inflammatory models of arachidonic acid and formalin. Phytochemical screening and high-performance liquid chromatography (HPLC) analysis of M. Indica confirmed the presence of mangiferin, quercetin, and isoquercetin. These phytoconstituents likely play a role in the observed biological activities. Our results show that M. indica has antioxidant, anti-inflammatory, and antipyretic effects, lending credence to its traditional use and advocating for its utilization as a viable contender in treating oxidative stress-associated ailments.

CONCLUSION: It is concluded that Magnifera indica has various properties in the treatment of various diseases.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.