Crosslinked carboxymethyl cellulose colloidal solution for cotton thread coating in wound dressing: A rheological study

Khairunnisa-Atiqah MK 1 , Salleh KM 2 , Hair AHA 3 , Mazlan NSN 1 , Mostapha M 4 , Zakaria S 5

Affiliations 

  • 1 Bioresources and Biorefinery Laboratory, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia
  • 2 Bioresource Technology Division, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia; Renewable Biomass Transformation Cluster, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia. Electronic address: kmsalleh@usm.my
  • 3 Bioresources and Biorefinery Laboratory, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia; Centre of Foundation Studies, Universiti Teknologi MARA, Cawangan Selangor, Kampus Dengkil, Dengkil 43800, Selangor, Malaysia
  • 4 Centre for Health Economic Research, Institute for Health System Research, National Institute of Health Malaysia, Shah Alam 40170, Malaysia
  • 5 Bioresources and Biorefinery Laboratory, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia. Electronic address: szakaria@ukm.edu.my
Int J Biol Macromol, 2023 Dec 31;253(Pt 8):127518.
PMID: 37865379 DOI: 10.1016/j.ijbiomac.2023.127518

Abstract

Cotton thread therapeutic properties as a wound dressing can be enhanced by utilising carboxymethyl cellulose-nanoparticles (CMC/NPs) colloidal solution as a coating solution. Nanoparticles such as graphene oxide (GO), graphene quantum dots (GQD), and silver nanoparticles (AgNP) stability in CMC was investigated through the rheological analysis and UV-Vis spectroscopy of the colloidal solutions. Citric acid (CA) acted as a crosslinker and was utilised to crosslink the colloidal solution with cotton thread. These CMC/NPs coated threads were subjected to mechanical properties and antibacterial activity analysis. Results obtained indicate less nanoparticle agglomeration and were stable in the CMC-based nanofluid. CMC/NPs rheological study suggested that colloidal solutions exhibited shear thinning behaviour and behaved as non-Newtonian fluids with n 

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