Affiliations 

  • 1 Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, 602105, India
  • 2 Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang (UMP), Lebuhraya Tun Razak, Gambang, 26300, Kunatan, Pahang, Malaysia
  • 3 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, 26300, Gambang, Kuantan, Pahang, Malaysia; Center for Advanced Intelligent Materials, Universiti Malaysia Pahang Al-Sultan Abdullah, 26300, Gambang, Kuantan, Pahang, Malaysia
  • 4 Center for Telecommunication Research & Innovation (CeTRI), Faculty of Electronics and Computer Technology and Engineering, Universiti Teknikal Malaysia Melaka (UTeM), Jalan Hang Tuah Jaya, Durian Tunggal, Melaka, 76100, Malaysia
  • 5 Center for Telecommunication Research & Innovation (CeTRI), Faculty of Electronics and Computer Technology and Engineering, Universiti Teknikal Malaysia Melaka (UTeM), Jalan Hang Tuah Jaya, Durian Tunggal, Melaka, 76100, Malaysia; Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, India. Electronic address: vigneswaran@utem.edu.my
Biosystems, 2024 Mar;237:105142.
PMID: 38340976 DOI: 10.1016/j.biosystems.2024.105142

Abstract

Single-cell analysis (SCA) improves the detection of cancer, the immune system, and chronic diseases from complicated biological processes. SCA techniques generate high-dimensional, innovative, and complex data, making traditional analysis difficult and impractical. In the different cell types, conventional cell sequencing methods have signal transformation and disease detection limitations. To overcome these challenges, various deep learning techniques (DL) have outperformed standard state-of-the-art computer algorithms in SCA techniques. This review discusses DL application in SCA and presents a detailed study on improving SCA data processing and analysis. Firstly, we introduced fundamental concepts and critical points of cell analysis techniques, which illustrate the application of SCA. Secondly, various effective DL strategies apply to SCA to analyze data and provide significant results from complex data sources. Finally, we explored DL as a future direction in SCA and highlighted new challenges and opportunities for the rapidly evolving field of single-cell omics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.