Fulltext

Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

Sun Y 1 , Tang H 2 , Du S 2 , Chen Y 1 , Ou Z 1 , Zhang M 1 Show all authors , Chen Z 2 , Tang Z 3 , Zhang D 3 , Chen T 2 , Xu Y 2 , Li J 2 , Norback D 4 , Hashim JH 5 , Hashim Z 6 , Shao J 3 , Fu X 7 , Zhao Z 2

Affiliations 

  • 1 Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China
  • 2 Department of Environmental Health, School of Public Health, Fudan University, NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai 200032, China
  • 3 Department of Pediatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • 4 Department of Medical Sciences, Uppsala University, Uppsala SE-751, Sweden
  • 5 Department of Environmental Health, Faculty of Health Sciences, Universiti Selangor, Shah Alam 40000, Malaysia
  • 6 Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, Serdang 43400, Malaysia
  • 7 Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China
Eco Environ Health, 2023 Dec;2(4):208-218.
PMID: 38435359 DOI: 10.1016/j.eehl.2023.08.001

Abstract

Indoor microorganisms impact asthma and allergic rhinitis (AR), but the associated microbial taxa often vary extensively due to climate and geographical variations. To provide more consistent environmental assessments, new perspectives on microbial exposure for asthma and AR are needed. Home dust from 97 cases (32 asthma alone, 37 AR alone, 28 comorbidity) and 52 age- and gender-matched controls in Shanghai, China, were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass spectrometry. Homes of healthy children were enriched with environmental microbes, including Paracoccus, Pseudomonas, and Psychrobacter, and metabolites like keto acids, indoles, pyridines, and flavonoids (astragalin, hesperidin) (False Discovery Rate 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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