Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats

Sankar A 1 , Kandasamy D 2 , Jones S 3 , Radhakrishan A 4 , Janaki CS 5 , Sheriff D 6 Show all authors , Prabhu K 7

Affiliations 

  • 1 Department of General Medicine, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India
  • 2 Department of Anatomy, Faculty of Medicine and Health Sciences, Quest International University, Ipoh Perak, Malaysia
  • 3 Department of Pharmacology and Therapeutics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
  • 4 Department of Microbiology, Faculty of Medicine, Quest International University, Ipoh Perak, Malaysia
  • 5 Department of Anatomy, Bharath Medical College and Hospital, Chennai, Tamil Nadu, India
  • 6 Department of Biochemistry, Anna Medical College, Montangne Blance, Mauritius
  • 7 Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
J Pharm Bioallied Sci, 2024 Apr;16(Suppl 2):S1824-S1828.
PMID: 38882815 DOI: 10.4103/jpbs.jpbs_9_24

Abstract

BACKGROUND: Neurodegenerative diseases induce amnesia, and effective treatment is still elusive. Aims and Objectives: The present study highlights the ameliorating effects of Manasa Mitra Vatakam (MMV) using behavioral parameters on scopolamine-induced memory loss in female Wistar rats.

MATERIALS AND METHODS: MMV was compared with DPZ as a standard in the present study to determine the behavioral parameters through elevated plus maze (Hebb William maze/rectangular maze)and locomotor activity in scopolamine-induced memory loss in female Wistar rats.

RESULTS AND DISCUSSION: The results of the study illustrate the effectiveness of MMV in reversing memory dysfunction and memory-enhancing effects.

CONCLUSION: The study paves the way for exploring research in CNS disorders and its potential application in drug-induced neurotoxicity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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