Affiliations 

  • 1 The Office of Research and Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur 613403, Tamil Nadu, India
World J Nephrol, 2024 Jun 25;13(2):95410.
PMID: 38983761 DOI: 10.5527/wjn.v13.i2.95410

Abstract

Renal epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells undergo biochemical changes and transform into mesenchymal-like cells, resulting in renal abnormalities, including fibrosis. EMT can cause diabetic nephropathy through triggering kidney fibrosis, inflammation, and functional impairment. The diverse molecular pathways that drive EMT-mediated renal fibrosis are not utterly known. Targeting key signaling pathways involved in EMT may help ameliorate diabetic nephropathy and improve renal function. In such settings, understanding precisely the complicated signaling networks is critical for developing customized therapies to intervene in EMT-mediated diabetic nephropathy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.