Game-changing breakthroughs to redefine the landscape of the renin-angiotensin-aldosterone system in health and disease

Balakumar P 1 , Jagadeesh G 2

Affiliations 

  • 1 The Office of Research & Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur 613 403, Tamil Nadu, India; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia
  • 2 Formerly, Office of Cardiology, Hematology, Endocrinology, and Nephrology, Center for Drug Evaluation and Research, US Food and Drug Administration, MD 20993, USA; Presently, Distinguished Visiting Professor, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. Electronic address: gjagadeesh2000@gmail.com
Cell Signal, 2025 Feb;126:111459.
PMID: 39389177 DOI: 10.1016/j.cellsig.2024.111459

Abstract

Novel perspectives on the role of the renin-angiotensin-aldosterone system (RAAS) offer a groundbreaking understanding of the system's role in health and illness. Our understanding of the role of the RAAS in several diseases, such as heart failure, hypertension, metabolic disorders, and chronic renal disease, has been broadened by recent studies. Specific variations in RAAS pathways can affect the course of disease and response to treatment, as shown by genetic and molecular research. The dynamic and fast-evolving nature of RAAS research described in this special issue might transform our approach to managing renal, neurological, and cardiovascular health, among other disease conditions, including cancer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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