Elevated serum soluble programmed death ligand 1 (sPD-L1) level correlate with clinical characteristics in breast cancer patients: A study at Hospital Universiti Sains Malaysia

Amira Khairil Anwar N 1 , Najmi Mohd Nazri M 1 , Rosliza Mohd Adzemi E 1 , Amilda Anthony A 1 , Mohd Azlan M 1 , Balakrishnan V 1 Show all authors , Mohd Fadzli Mustaffa K 1 , Mazuwin Yahya M 2 , Haron J 2 , Ahmad Damitri Al-Astani Tengku Din T 2 , Soon Lai L 3 , Aizuddin Kamaruddin M 3 , Fatmawati Mokhtar N 4

Affiliations 

  • 1 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
  • 2 Breast Cancer Awareness & Research Unit (BestARi), Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kampus Kesihatan, Jalan Raja Perempuan Zainab 2, 16150 Kota Bharu, Kelantan, Malaysia
  • 3 Agilent Technologies LDA Malaysia Sdn. Bhd., Bayan Lepas, 11900 Bayan Lepas, Penang, Malaysia
  • 4 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: fatmawati@usm.my
Cytokine, 2024 Jul 22;182:156698.
PMID: 39042994 DOI: 10.1016/j.cyto.2024.156698

Abstract

BACKGROUND: Elevated serum levels of soluble PD-L1 (sPD-L1) have been reported in many cancers; however, there is limited data of sPD-L1 in breast cancer, especially those representing Asian (Malay) women. The purpose of this study was to evaluate sPD-L1 serum levels and analyze its correlation with clinical characteristics in breast cancer patients at Hospital Universiti Sains Malaysia (HUSM).

METHODS: Blood specimens were obtained from 92 malignant, 16 benign breast cancer patients and 23 healthy controls. The serum concentrations of sPD-L1 were assessed by enzyme-linked immunosorbent assay (ELISA).

RESULTS: The median serum sPD-L1 concentration of malignant and benign breast cancer patients was significantly elevated compared to the healthy cohorts (12.50 ng/mL vs 13.97 ng/mL vs 8.75 ng/mL, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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