An Analysis of the Radiosensitiser Applications in the Biomedical Field

Lim TS 1 , Abdul Rahman I 1 , Umar A 2 , Mohd Hidzir N 1 , Paul Arkill K 3 , Sharif R 4 Show all authors , Jonet MA 5 , Munawar Kabir Mohd H 1 , Mohamed F 1

Affiliations 

  • 1 Department of Applied Physics, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor Darul Ehsan, Malaysia
  • 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia
  • 3 University of Nottingham Biodiscovery Institute, Medicine, University of Nottingham, Nottingham, NG7 2RD, United Kingdom
  • 4 Nutritional Science Program and Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, Kuala Lumpur, Malaysia
  • 5 Malaysia Genome & Vaccine Institute, National Institute of Biotechnology Malaysia, Jalan Bangi, 43000, Kajang, Selangor, Malaysia
Curr Radiopharm, 2024 Sep 02.
PMID: 39225213 DOI: 10.2174/0118744710269842240825160247

Abstract

BACKGROUND: Various types of radiosensitisers have been introduced from the past until the present day for applications in the biomedical field. However, there is a lack of understanding and comparison between the various parameters introduced in addition to a lack of consensus among researchers on the optimal radiosensitiser for applications in the biomedical field.

OBJECTIVE: This review aimed to investigate the usage of radiosensitisers in the biomedical field, determine their important parameters, and suggest radiosensitisers with potential among the analysed radiosensitisers.

RESULTS AND CONCLUSION: This review has discussed several parameters for radiosensitisers, including median lethal dose, cell survival, tumour size, cell viability, Dose Enhancement Factor (DEF), Reactive Oxygen Species (ROS) concentration, radiosensitiser production complexity, radiosensitiser administration technique, and radiosensitiser toxicity. General trends regarding the development of radiosensitisers, including the types, effectiveness, and their production complexity, have also been discussed within this review article.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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