Affiliations 

  • 1 Centre for Translational Research, IMU Institute for Research and Development (IRDI), International Medical University (IMU), Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia
  • 2 Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia
  • 3 Warwick Medical School, University of Warwick, Coventry CV4 7HL, UK
  • 4 Dalhousie Medicine DMNS, Dalhousie University, 5849 University Avenue, Halifax, NS B3H 4R2, Canada
Nutrients, 2022 Oct 02;14(19).
PMID: 36235756 DOI: 10.3390/nu14194104

Abstract

Personalized nutrition is an approach that tailors nutrition advice to individuals based on an individual's genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been adequately explored. Hence, a systematic review of randomized trials reporting on the effects of personalized nutrition on dietary, physical activity, and health outcomes was conducted. A systematic search of seven electronic databases and a manual search resulted in identifying nine relevant trials. Cochrane's Risk of Bias was used to determine the trials' methodological quality. Although the trials were of moderate to high quality, the findings did not show consistent benefits of personalized nutrition in improving dietary, behavioral, or health outcomes. There was also a lack of evidence from regions other than North America and Europe or among individuals with diseases, affecting the generalizability of the results. Furthermore, the complex relationship between genes, interventions, and outcomes may also have contributed to the scarcity of positive findings. We have suggested several areas for improvement for future trials regarding personalized nutrition.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.