Alkaloids and Styryl Lactones from Goniothalamus tortilipetalus and Their Biological Activities

Champakam S 1 , Patrick BO 2 , Injan N 3 , Nokbin S 4 , Cheenpracha S 3 , Loh ZH 5 Show all authors , Maneerat T 6 , Winyayong P 7 , Promnart P 7 , Mah SH 5 , Andersen RJ 2 , Laphookhieo S 1

Affiliations 

  • 1 Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand
  • 2 Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
  • 3 Division of Chemistry, School of Science, University of Phayao, Phayao 56000, Thailand
  • 4 Laboratory for Computational and Applied Chemistry, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
  • 5 School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Lakeside Campus, 47500, Subang Jaya, Selangor, Malaysia
  • 6 Medicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai, 57100, Thailand
  • 7 School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand
J Nat Prod, 2024 Nov 07.
PMID: 39508737 DOI: 10.1021/acs.jnatprod.4c00933

Abstract

Phytochemical investigations of the twig and leaf extracts of Goniothalamus tortilipetalus resulted in the isolation and identification of two new alkaloids, goniotortiline (1) and goniotortilactam (2), three new styryl lactone derivatives, goniotortilactone (3) and goniotortilols A (4) and B (5), and 25 known compounds. Their structures were elucidated by spectroscopic methods and HRESITOFMS data. Compounds 5, 13, 15, 16, 22, and 30 inhibited nitric oxide (NO) production with IC50 values ranging from 8.7 ± 0.1 to 17 ± 1 μM, revealing stronger effects than the standard drug, dexamethasone (IC50 16.9 ± 2.2 μM), and compound 30 possessed the most potent NO production inhibition. Compounds 12 and 29 demonstrated notable efficacy in enhancing glucose consumption with IC50 values of 77 ± 4 and 66 ± 4 μM, respectively, while their glucose uptakes were 1.7- and 2-fold, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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