Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths

Saleh RO 1 , Hamad HA 2 , Najim MA 3 , Menon SV 4 , Kaur M 5 , Sivaprasad GV 6 Show all authors , Abohassan M 7 , Juan WT 8 , Husseen B 9 , Mustafa YF 10

Affiliations 

  • 1 Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al Maarif, Anbar, Iraq. Dr.raed.obaid@uoa.edu.iq
  • 2 Department of Pathological Analysis, Collage of Applied Sciences, University of Fallujah, Fallujah, Iraq
  • 3 Department of Biology, College Education for Pure Science, University of Anbar, Al-Anbar, Iraq
  • 4 Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
  • 5 Department of Sciences, Vivekananda Global University, Jaipur, Rajasthan, India
  • 6 Department of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India
  • 7 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
  • 8 Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
  • 9 Medical Laboratory Technique college, The Islamic University, Najaf, Iraq
  • 10 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
Cell Biochem Biophys, 2024 Nov 20.
PMID: 39567423 DOI: 10.1007/s12013-024-01617-x

Abstract

Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells in liver tissue. The secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease. They transport various payloads, such as proteins, DNAs, and RNAs, and enable cell interaction to regulate myriad physiological and pathological processes in liver tissue. Long non-coding RNAs (lncRNAs) are a crucial component of exosomes with an excellent capability to regulate multiple cellular activities such as differentiation, development, metabolism, proliferation, apoptosis, and activation. With the advancements in transcriptomic and genomic study methods and database management technology, the functions and mechanisms of exosomal lncRNAs in liver diseases have been well-studied. This article delves into the detailed role of exosomal lncRNAs in liver disease onset and progression, ranging from hepatocellular carcinoma (HCC) to liver fibrosis drug-induced liver damage (DILI) and steatotic liver diseases.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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