Dual role of mesenchymal stem/stromal cells and their cell-free extracellular vesicles in colorectal cancer

Saadh MJ 1 , Mohamed AH 2 , Almoyad MAA 3 , Allela OQB 4 , Amin AH 5 , Malquisto AA 6 Show all authors , Jin WT 7 , Sârbu I 8 , AlShamsi F 9 , Elsaid FG 10 , Akhavan-Sigari R 11

Affiliations 

  • 1 Faculty of Pharmacy, Middle East University, Amman, Jordan
  • 2 Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babil, Hilla, Iraq
  • 3 Department of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Mushait, Saudi Arabia
  • 4 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq
  • 5 Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt
  • 6 Abuyog Community College, Abuyog Leyte, Philippines
  • 7 Department of Science and Technology, Faculty of Humanities, Management and Science, Universiti Putra Malaysia Bintulu Campus, Sarawak, Malaysia
  • 8 2nd Department of Surgery-Pediatric Surgery and Orthopedics, "Grigore T. Popa" University of Medicine and Pharmacy, Romania
  • 9 Dubai Health Authority, Primary Health Care Department, Dubai, United Arab Emirates
  • 10 Biology Department, College of Science, King Khalid University, Asir, Abha, Al-Faraa, Saudi Arabia
  • 11 Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany
Cell Biochem Funct, 2024 Mar;42(2):e3962.
PMID: 38491792 DOI: 10.1002/cbf.3962

Abstract

Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell-cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell-free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC-derived exosomes for possible cell-free therapy in CRC.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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