Phytochemical Profiling and Biological Activities of Nigella sativa Vinegar Extract: An Insight Into Hypoglycemic Potential Using In Vivo and In Silico Studies

Akhtar MT 1 , Qadir R 2 , Altaf U 3 , Almas T 4 , Batool S 4 , Ikram MS 5 Show all authors , Meor Hussin AS 2 , Perveen K 6 , Alshaikh NA 6 , Saadia M 7

Affiliations 

  • 1 Institute of Chemistry, University of Sargodha, Sargodha, Punjab, Pakistan
  • 2 Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
  • 3 Department of Chemistry, Govt. Queen Mary Graduate College, Lahore, Punjab, Pakistan
  • 4 Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan
  • 5 Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University, Xiamen, China
  • 6 Department of Botany & Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
  • 7 Department of Biochemistry, Government College Women University, Faisalabad, Pakistan
Chem Biodivers, 2024 Dec 29.
PMID: 39804576 DOI: 10.1002/cbdv.202402512

Abstract

The current study was conducted to characterize the vinegar extract of Nigella sativa and evaluate its biological activities using in vitro and in vivo studies. The N. sativa extract (NSE) was prepared by macerating seeds in a mixture of water and synthetic vinegar (1:10). The antioxidant potential of NSE was assessed, revealing high total phenolic contents (431.66 mg/100 g), total flavonoid contents (73.45 mg/100 g), total antioxidant capacity (118.55 mg/100 g), and strong radical scavenging potential (89.67%). The anticancer activity of NSE showed insignificant cytotoxic effects on HepG2 liver cell lines (96.61 ± 3.00). An in vivo animal trial was performed, and NSE significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications