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Mpox Virus as a Global Public Health Emergency: A Scoping Review

Sankar S 1 , Balakrishnan P 2 , Yong YK 3 , Raju S 4 , Velu V 5 , Shankar EM 6 Show all authors , Larsson M 7

Affiliations 

  • 1 Department of Microbiology, Centre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, Tamil Nadu, India
  • 2 Department of Research, Meenakshi Academy of Higher Education and Research (MAHER), Chennai 600078, Tamil Nadu, India
  • 3 Laboratory Center, Xiamen University Malaysia, Sepang 43900, Selangor, Malaysia
  • 4 State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet, Chennai 600006, Tamil Nadu, India
  • 5 Department of Pathology and Laboratory Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Emory University School of Medicine, Atlanta 30329, Georgia, USA
  • 6 Department of Biotechnology, Infection and Inflammation, Central University of Tamil Nadu, Thiruvarur 610005, Tamil Nadu, India
  • 7 Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, Linköping 58183, Sweden
Can J Infect Dis Med Microbiol, 2025;2025:6683501.
PMID: 39885897 DOI: 10.1155/cjid/6683501

Abstract

The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science. This comprehensive analysis describes the virus epidemiology, pathogenesis, clinical manifestations, complications including secondary bacterial infections, diagnosis, treatment and vaccination. The article underscores the significance of key viral and immune mediators of infection and discusses updated recommendations on therapeutic strategies and vaccination.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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