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Current trends and research advances on the application of TiO2 nanoparticles in dentistry: How far are we from clinical translation?

Mohammadi H 1 , Moradpoor H 2 , Beddu S 3 , Mozaffari HR 4 , Sharifi R 5 , Rezaei R 6 Show all authors , Fallahnia N 7 , Ebadi M 8 , Mazlan SA 8 , Safaei M 6

Affiliations 

  • 1 School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, Nibong Tebal, 14300, Penang, Malaysia
  • 2 Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 3 Institute of Energy Infrastructure (IEI), Department of Civil Engineering, College of Engineering, Universiti Tenaga Nasional, Jalan IKRAM-UNITEN, 43000, Kajang, Selangor, Malaysia
  • 4 Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 5 Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 6 Advanced Dental Science and Technology Research Center, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 7 Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 8 Engineering Materials and Structures (eMast) Ikohza, Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, Kuala Lumpur 54100, Malaysia
Heliyon, 2025 Feb 15;11(3):e42169.
PMID: 39991247 DOI: 10.1016/j.heliyon.2025.e42169

Abstract

The great potential of nanotechnology-based knowledge during the past decade has shown great potential to elevate human living standards and enhance healthcare conditions through diagnosing, preventing, and treating different diseases. Among abundant nanoparticles (NPs), inorganic NPs feature distinctive biological and physicochemical properties compared to their conventional counterparts which do not endow. TiO2 NPs possess excellent properties including low-cast, antibacterial properties, biocompatibility, and physicochemical stability. The present review highlights and discusses the current trends in applying TiO2 NPs in dentistry ranging from TiO2-based nanocomposite in endodontics, orthodontics, and biofilm prevention. Moreover, the potential of TiO2 NPs in developing new photodynamic therapy and the next generation of oral care products is outlined. In the end, the clinical translation of TiO2-based dental materials is brought to the forefront which is impetus and of great importance to developing inorganic NP-based dental materials.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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