Prevalence of carbapenem-resistant E. coli and Klebsiella spp: a systematic review and meta-analysis of non-clinical isolates from Nigeria

Irekeola AA 1 , Shueb RH 1 , Engku Abd Rahman ENS 1 , Bello KE 2 , Elmi AH 1 , Afolabi HA 3 Show all authors , Sabour AA 4 , Alshiekheid MA 4 , Al Kaabi NA 5 , Al-Subaie MF 6 , Rabaan AA 7

Affiliations 

  • 1 Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 2 Department of Microbiology, Faculty of Natural Science, Kogi State (Prince Abubakar Audu) University, Anyigba, Kogi State, Nigeria
  • 3 Department of General Surgery, School of Medical Sciences, Hospital Universiti Sains Malaysia, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 4 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
  • 5 College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates
  • 6 Research Center, Dr. Sulaiman Alhabib Medical Group, Riyadh, Saudi Arabia
  • 7 College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
Pathog Glob Health, 2025 Mar 20.
PMID: 40111025 DOI: 10.1080/20477724.2025.2479971

Abstract

The issue of bacterial resistance remains a significant public health problem, with carbapenem-resistant Klebsiella spp and E. coli having adverse effects on agriculture and healthcare. Nonetheless, the true prevalence of CRE in non-clinical settings in Nigeria is unknown. Thus, for the first time, this study undertook a systematic review and meta-analysis to offer comprehensive data on the prevalence of carbapenem-resistant E. coli and Klebsiella spp in non-clinical isolates from Nigeria. The guideline of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) was followed. Multiple databases were searched for relevant studies and data from eligible studies were analyzed using the random effect model. From 321 retrieved records, 17 were included. The pooled prevalence of carbapenem-resistant E. coli was 14.2% (95% CI: 4.6-36.0, I2 = 94.51, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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