Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Kow CS 1 , Ramachandram DS 2 , Hasan SS 3 , Thiruchelvam K 1

Affiliations 

  • 1 School of Pharmacy, IMU University, Kuala Lumpur, Malaysia
  • 2 School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia
  • 3 School of Applied Sciences, University of Huddersfield, Huddersfield, UK
Australas J Dermatol, 2025 Mar 25.
PMID: 40130783 DOI: 10.1111/ajd.14466

Abstract

This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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