Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome

Tiong WN; Sim EU; Fong AY; Ong TK

doi:10.1016/j.jcdr.2012.08.004

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Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome

Tiong WN ¹ , Sim EU , Fong AY , Ong TK

Affiliations

¹ Clinical Research Centre, Sarawak General Hospital, Malaysia ; Faculty of Resource Science and Technology, University Malaysia Sarawak, Kota Samarahan, Malaysia

J Cardiovasc Dis Res, 2013 Mar;4(1):3-6.

PMID: 24023462 DOI: 10.1016/j.jcdr.2012.08.004

Abstract

BACKGROUND: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD).

MATERIALS AND METHODS: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls.

RESULTS: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.