Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells

Fong LY 1 , Ng CT 1 , Cheok ZL 1 , Mohd Moklas MA 2 , Hakim MN 1 , Ahmad Z 3

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • 2 Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
  • 3 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address: zuraini@upm.edu.my
Phytomedicine, 2016 Feb 15;23(2):191-9.
PMID: 26926181 DOI: 10.1016/j.phymed.2015.11.019

Abstract

Endothelial cell activation is characterized by increased endothelial permeability and increased expression of cell adhesion molecules (CAMs). This allows monocyte adherence and migration across the endothelium to occur and thereby initiates atherogenesis process. Asiatic acid is a major triterpene isolated from Centella asiatica (L.) Urban and has been shown to possess anti-oxidant, anti-hyperlipidemia and anti-inflammatory activities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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