Novel MDM2 splice variants identified from oral squamous cell carcinoma

Sam KK 1 , Gan CP , Yee PS , Chong CE , Lim KP , Karen-Ng LP Show all authors , Chang WS , Nathan S , Rahman ZA , Ismail SM , Cheong SC

Affiliations 

  • 1 Oral Cancer Research Team, Cancer Research Initiatives Foundation, 2nd Floor Outpatient Centre, Sime Darby Medical Centre, Subang Jaya, Malaysia
Oral Oncol, 2012 Nov;48(11):1128-35.
PMID: 22705356 DOI: 10.1016/j.oraloncology.2012.05.016

Abstract

The presence of a variety of MDM2 splice variants has been reported in a range of different tumor types and is associated with poor patient prognosis. Furthermore, several MDM2 variants have been shown to have oncogenic properties. Despite this, MDM2 splice variants have not been comprehensively characterized in oral squamous cell carcinoma (OSCC).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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