Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

Mohamed AF 1 , Kristoffersson AN 2 , Karvanen M 3 , Nielsen EI 4 , Cars O 3 , Friberg LE 4

Affiliations 

  • 1 Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden Institute for Medical Research, Kuala Lumpur, Malaysia
  • 2 Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden anders.kristoffersson@farmbio.uu.se
  • 3 Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden
  • 4 Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
J Antimicrob Chemother, 2016 May;71(5):1279-90.
PMID: 26850719 DOI: 10.1093/jac/dkv488

Abstract

Combination therapy can be a strategy to ensure effective bacterial killing when treating Pseudomonas aeruginosa, a Gram-negative bacterium with high potential for developing resistance. The aim of this study was to develop a pharmacokinetic/pharmacodynamic (PK/PD) model that describes the in vitro bacterial time-kill curves of colistin and meropenem alone and in combination for one WT and one meropenem-resistant strain of P. aeruginosa.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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