Development of an algorithm of satellite markers for monitoring chimerism status in post-allogeneic haematopoietic stem cell transplantation patients

Choong SS 1 , Rosmanizam S , Ibrahim K , Gan GG , Ariffin H

Affiliations 

  • 1 Paediatric Oncology, University of Malaya, Kuala Lumpur, Malaysia
Int J Lab Hematol, 2011 Apr;33(2):182-6.
PMID: 20868447 DOI: 10.1111/j.1751-553X.2010.01264.x

Abstract

Analysis of variable number tandem repeats (VNTRs) by polymerase chain reaction (PCR) is a common method used to predict engraftment status in post-allogeneic haematopoeitic stem cell transplantation (HSCT) patients. Different populations have different copies of repeated DNA sequence and hence, different percentage of informativeness between patient and donor.

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