Fulltext

Roles of cofactors and chromatin accessibility in Hox protein target specificity

Beh CY 1 , El-Sharnouby S 2 , Chatzipli A 3 , Russell S 4 , Choo SW 1 , White R 2

Affiliations 

  • 1 Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY UK
  • 3 Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY UK ; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH UK
  • 4 Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH UK ; Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR UK
Epigenetics Chromatin, 2016;9:1.
PMID: 26753000 DOI: 10.1186/s13072-015-0049-x

Abstract

The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood. This is well illustrated by the Hox family of transcription factors as their limited in vitro DNA-binding specificity contrasts with their clear in vivo functional specificity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications