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Bisphenol A, Dichlorodiphenyltrichloroethane (DDT) and Vinclozolin Affect ex-vivo Uterine Contraction in Rats via Uterotonin (Prostaglandin F2α, Acetylcholine and Oxytocin) Related Pathways

Salleh N , Giribabu N 1 , Feng AO , Myint K

Affiliations 

  • 1 1. Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia; ; 2. Department of Biomedical Science, Faculty of Health and Life Sciences, Management and Science University, Shah Alam, 40100 Selangor Darul Ehsan, Malaysia
Int J Med Sci, 2015;12(11):914-25.
PMID: 26640411 DOI: 10.7150/ijms.11957

Abstract

Bisphenol-A (BPA), dichrolodiphenyltrichloroethane (DDT) and vinclozolin were found able to induce abnormal uterine contraction. The mechanisms involved remains unclear. We hypothesized that the effect of these compounds were mediated via the uterotonin pathways. Therefore, in this study, effects of BPA, vinclozolin and DDT-only and in combination with uterotonins (PGF-2α, acetylcholine and oxytocin) on the force and pattern of uterine contraction were observed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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