Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection

Saeidi A 1 , Buggert M 2 , Che KF 3 , Kong YY 1 , Velu V 4 , Larsson M 5 Show all authors , Shankar EM 6

Affiliations 

  • 1 Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia
  • 2 Department of Microbiology, University of Pennsylvania, USA
  • 3 Institute for Environmental Medicine, Karolinska Institute, Solna, 17 177 Stockholm, Sweden
  • 4 Department of Microbiology and Immunology, Emory University, GA, Atlanta, USA
  • 5 Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  • 6 Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia; Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. Electronic address: shankarem@um.edu.my
Cell Immunol, 2015 Nov-Dec;298(1-2):126-33.
PMID: 26520669 DOI: 10.1016/j.cellimm.2015.10.009

Abstract

Understanding the mechanisms involved in cellular immune responses against control of human immunodeficiency virus (HIV) infection is key to development of effective immunotherapeutic strategies against viral proliferation. Clear insights into the regulation of cytotoxic CD8+ T cells is crucial to development of effective immunotherapeutic strategies due to their unique ability to eliminate virus-infected cells during the course of infection. Here, we reviewed the roles of transcription factors, co-inhibitory molecules and regulatory cytokines following HIV infection and their potential significance in regulating the cytotoxic potentials of CD8+ T cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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