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Does glucose-6-phosphate dehydrogenase deficiency modify the course of leprosy or its treatment

Pettit JHS 1 , Chin J 2

Affiliations 

  • 1 J. H. S. PETTIT, MD, MRCP. The Research Unit, Sungei Buloh Leprosarium, Selangor, Malaysia, and National Institute for Medical Research, Mill Hill, London, N.W. 7, England
  • 2 JAMES CHIN, MD, MPH. Institute for Medical Research, Kuala Lumpur, Malaysia, and the Hooper Foundation, University of California, San Francisco 22, California, USA
Lepr Rev, 1964 Jul;35(4):149-56.
PMID: 14177689

Abstract

In a survey of over 1,000 patients with leprosy, 47 cases ( 4.4 per cent) were found to have glucose-6-phosphate dehydrogenase deficiency. A controlled clinical study suggests that such a deficiency does not modify the overall response to therapy but may predispose to a greater tendency to leprosy reactions. All patients were receiving 600 to 800 mgm. of sulphone per week and none had a frank haemolytic anaemia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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