• 1 EA921 SONAS, SFR4207 QUASAV, Université d'Angers , Angers, France
  • 2 INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie , LabEx IGO and LabEx Transplantex, Nantes, France
  • 3 Laboratoire MOLTECH-Anjou, CNRS UMR6200, Université d'Angers , Angers, France
  • 4 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN) , CNRS, LabEx CEBA, Gif-sur-Yvette, France
  • 5 Department of Chemistry, Faculty of Science, University of Malaya , Kuala Lumpur, Malaysia
J Nat Prod, 2015 Sep 25;78(9):2187-97.
PMID: 26301802 DOI: 10.1021/acs.jnatprod.5b00222


Phytochemical investigation on the fruits of Mesua lepidota (Calophyllaceae) led to the isolation of seven new phenylcoumarin derivatives named lepidotols A-E (1-5) and lepidotins A and B (6, 7). These structures were elucidated by spectroscopic and spectrometric methods including UV, NMR, and HRMS. Lepidotol A (1), the major compound, was evaluated for its inhibitory effect on inflammation and immunity using endothelial cell-based cellular assays. At 10 μM, 1 exhibited an anti-inflammatory activity, with a significant inhibition of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression induced by tumor necrosis factor-α. Lepidotol A also showed a mild immunosuppressive effect, with inhibition of the major histocompatibility complex molecules, namely, human leukocyte antigen (HLA)-DR and HLA-E.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.