his is a short report on the recent investigation on the anticancer and antioxidant potential
of Pseuduvaria macrophylla stem bark and leaf extract on human breast cancer cell (MCF-7), human
prostate cancer cell (PC-3) and human colon cancer cell (HT29). LCMS experiment was done to
identify the chemical composition in the methanolic extracts while GCMS analysis was done to
determine the chemical composition in the hexanolic extracts. For antioxidant activity, the most active
extract was leaf methanolic with 69.22 % of DPPH inhibition. Additionally, the leaf methanolic extract
inhibited the better proliferation especially on human breast cancer cell (MCF-7) compared to hexane
crude extracts due to more than 90% of cancer cell death and lowest IC50 value at range of 80.70
µg/mL ± 0.08 – 106.70 µg/mL ± 0.07. The major detected compounds were α-Cadinol, neophytadiene,
palmitic acid, linoleic acid, oleic acid and isopolycerasoidal and isopolycerasoidal methyl ester. The
findings of this study support the anti-cancer claims of Pseuduvaria macrophylla leaf. Copyright© 2016
Penerbit Akademia Baru- All rights reserved.