Fatigue due to driving is an important aspect in maintaining drivers’ performance and safety. There are many studies linking fatigue to reduction in performance and increase in accident risk. There are also some signs linking road and vehicle vibrations to fatigue, but this not been thoroughly investigated. Experiments have been made to detect and quantify levels of driving fatigue in human, usually involving driving over long distance of highway or normal roads. However, these methods are quite time consuming, high cost, hard to control and also potentially high risk. With the development of better display, computing power and motion technologies, driving simulators are becoming more and more realistic each year. With this insight, it is proposed that these driving simulators can be used as a tool to study human fatigue, where they can counter the above shortcomings significantly. This paper will review different methods conducted in past published works to investigate the viability and validity of using driving simulators as a tool for studying vibration matters and its effects on human fatigue. In this paper, there were twenty past studies have been reviewed in term of its simulator design and its study design. The selection is based on these keywords; simulator, fatigue, vibration, human and driver and all papers were filtered from 1990s to current year.