Affiliations 

  • 1 Department of Neurosurgery, The Jinjiang City Hospital, Jinjiang, 362200, Fujian, China
Tumour Biol., 2015 Jun;36(6):4089.
PMID: 26025112 DOI: 10.1007/s13277-015-3481-4

Abstract

With great interest, we read the article "Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis" (by Xiao et al. Tumor Biol 35(7):6687-6693, 2014), which has reached important conclusions that the phosphatase and tensin homolog (PTEN) gene mutations were closely related to poor prognosis of glioma patients. Through quantitative analysis, the investigators (Xiao WZ et al.) showed that glioma patients with PTEN gene mutations exhibited a significantly shorter overall survival (OS) than those without PTEN gene mutations (HR = 3.66, 95 % CI = 2.02∼5.30, P  0.05). The meta-analysis results are encouraging. Nevertheless, some deficiencies still existed that we would like to raise.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.