Women of childbearing age with epilepsy are often concerned about hazards of antiepileptic drugs exposure on their baby, during pregnancy and lactation. Valproic acid (VPA) is a well-established human teratogen that is frequently prescribed in the treatment of epilepsy, migraines, and bipolar affective disorder. We investigate the protective effect of Nigella sativa (NS) oil extract on the spinal neurons and glia cells damage induced by prenatal VPA administration on the morphology of mice embryos spinal cord and placenta. Five groups of six pregnant mice each were used for the study. Group 1 was administered VPA 600mg/kg/day, group 2 and 3 had VPA 600mg/kg/day and 0.1ml and 0.2ml of NS oil respectively, group 4 received VPA 600mg/kg and folic acid 400µg daily. The fifth group had saline only and served as control. The treatment were given orally from GD 9 to GD 11. The dams were sacrificed on GD 15 and the embryos with the placenta were explanted from the uterus and fixed in 4% formaldehyde and processed for H&E and examine with Nikon image analyser. The histopathological changes in the spinal cord of VPA exposed embryos include distortion in the central canal and gray matter of the spinal cord, which were found to be prevented by administering NS with VPA. Necrosis that was recorded in the placenta of VPA only treated dams was also prevented by NS. In conclusion we proposed NS oil extract can be used in preventing histopathological effects of VPA on the spinal cord cell of mice embryos and placenta.