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The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Velapasamy S 1 , Dawson CW 2 , Young LS 3 , Paterson IC 4 , Yap LF 5

Affiliations 

  • 1 Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. vsharmila84@gmail.com
  • 2 Institute of Cancer and Genomic Medicine, University of Birmingham, Birmingham B15 2TT, UK. c.w.dawson@bham.ac.uk
  • 3 Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. L.S.Young@warwick.ac.uk
  • 4 Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. ipaterson@um.edu.my
  • 5 Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. yapleefah@um.edu.my
Cancers (Basel), 2018 Jul 27;10(8).
PMID: 30060514 DOI: 10.3390/cancers10080247

Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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