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In vitro evaluation of bioactivity of chemically deposited hydroxyapatite on polyether ether ketone

Almasi D 1 , Izman S 2 , Sadeghi M 3 , Iqbal N 4 , Roozbahani F 5 , Krishnamurithy G 6 Show all authors , Kamarul T 7 , Abdul Kadir MR 4

Affiliations 

  • 1 Department of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia ; Medical Devices & Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
  • 2 Department of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
  • 3 Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia
  • 4 Medical Devices & Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
  • 5 Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
  • 6 Institute of Translational Medicine, University of Liverpool, Sherrington Building, Liverpool L69 3GE, UK ; Department of Orthopaedic Surgery, NOCERAL, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 7 Department of Orthopaedic Surgery, NOCERAL, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Int J Biomater, 2015;2015:475435.
PMID: 25838826 DOI: 10.1155/2015/475435

Abstract

Polyether ether ketone (PEEK) is considered the best alternative material for titanium for spinal fusion cage implants due to its low elasticity modulus and radiolucent property. The main problem of PEEK is its bioinert properties. Coating with hydroxyapatite (HA) showed very good improvement in bioactivity of the PEEK implants. However the existing methods for deposition of HA have some disadvantages and damage the PEEK substrate. In our previous study a new method for deposition of HA on PEEK was presented. In this study cell proliferation of mesenchymal stem cell and apatite formation in simulated body fluid (SBF) tests were conducted to probe the effect of this new method in improvement of the bioactivity of PEEK. The mesenchymal stem cell proliferation result showed better cells proliferation on the treated layer in comparison with untreated PEEK. The apatite formation results showed the growth of the HA on the treated PEEK but there was not any sight of the growth of HA on the untreated PEEK even after 2 weeks. The results showed the new method of the HA deposition improved the bioactivity of the treated PEEK in comparison with the bare PEEK.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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