Substance abuse is an epidemic that spreads among adults, adolescents and even children in Malaysia. Substance abuse is categorized as a mental disorder, whereby, Cognitive Behavioural Therapy (CBT) is an approach that provides face to face physiological therapy for patients could resolve this issue. Computerized Cognitive Behavioural Therapy (CCBT) is a progression of information technology that is provided for patients encounter substance abuse. CCBT is a computerized therapy conducted at patient’s own pace. Ensuring patient’s continuous engagement towards CCBT becomes an issue. Patients that experience early gains, loss of interest and improvement symptom would sign up for alternative services that eventually causes disengagement and dropout from CCBT program. Interface design for CCBT is known as one of the important elements that effects patient’s engagement along CCBT program. Therefore, in this study, influential factors regarding CCBT’s interface design was investigated, whereby, five prominent models was reviewed. Content analysis methodology was employed to discover influential factors regarding CCBT’s interface design. Four influential factors was discovered namely engagement, dropout, culture and interface. These factors are known to ensure patient’s continuous engagement towards CCBT program. CCBT’s interface design plays a vital role in delivering the therapy program. Indirectly, CCBT’s interface design plays an important role to ensure patient’s continuous engagement till the completion of CCBT program. Therefore, these factors would guide researcher, service provider, developers and clinicians in designing engaging interface for CCBT.