Dengue is a neglected disease caused by the infection of dengue virus which is transmitted
by Aedes mosquitoes and to some, it could be fatal. Regardless of the enormous work devoted to
research for the treatment of dengue, to this day there is no cure, and treatment is solely limited to
supportive care by treating the symptoms. The inhibition of the viral RNA non-structural enzymes
has been the most popular approach amongst the strategies applied to the search and development
of dengue antivirals. This review is a compact digest of what is already known of the roles and the
prospects of the dengue virus non-structural proteins NS1, NS2BNS3, NS4A, NS4B and NS5 as the
targets for antiviral studies including the recent progress that has been published regarding their
roles.