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Conjugation of insulin onto the sidewalls of single-walled carbon nanotubes through functionalization and diimide-activated amidation

Ng CM 1 , Loh HS 2 , Muthoosamy K 1 , Sridewi N 3 , Manickam S 1

Affiliations 

  • 1 Manufacturing and Industrial Processes Research Division, Faculty of Engineering, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia
  • 2 Faculty of Science, School of Biosciences, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia
  • 3 Faculty of Science and Defence Technology, National Defence University of Malaysia, Kuala Lumpur, Malaysia
Int J Nanomedicine, 2016;11:1607-14.
PMID: 27143882 DOI: 10.2147/IJN.S98726

Abstract

The high aspect ratio of carbon nanotubes (CNTs) allows the attachment of compounds that enhance the functionality of the drug vehicle. Considering this, use of CNTs as a multifunctional insulin carrier may be an interesting prospect to explore.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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