Rubberwood is the most popular timber for furniture manufacturing industry in Malaysia. Major drawback concerned
that rubberwood is very prone to attack by fungi and wood borers, and the preservation method using boron compounds
exhibited hazardous effect to the workers. Fungal-based biological control agents have gained wide acceptance and
Schizophyllum commune secondary metabolite played an important role in term of antifungal agent productivity. The
effects of initial pH, incubation temperature and agitation on biomass production by S. commune were investigated
under submerged shake culture. In this work, it was found that the synthetic medium with initial solution pH of 6.5
and incubated at 30ºC with shaking at 150 rpm provided the highest biomass production. The biomass extract from
S. commune was then applied onto the rubberwood block panel to investigate its effectiveness. The results showed
that biomass extract at a concentration of 5 µg/µL could inhibit the growth of selected rubberwood-degrading fungi,
such as Lentinus sp., L. strigosus and Pycnoporus sanguineus.