Tocotrienol preserves ovarian function in cyclophosphamide therapy

Saleh HS 1 , Omar E 2 , Froemming GR 3 , Said RM 4

Affiliations 

  • 1 Faculty of Health Science, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia Department of Biology, Faculty of Pure Science Education, Thi-Qar University, Thi-Qar, Iraq
  • 2 Faculty of Medicine, Institute of Medical Molecular Biotechnology, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia Centre for Pathology Diagnostic and Research Laboratories, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia effat@salam.uitm.edu.my
  • 3 Faculty of Medicine, Institute of Medical Molecular Biotechnology, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia
  • 4 Faculty of Health Science, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia
Hum Exp Toxicol, 2015 Oct;34(10):946-52.
PMID: 25585998 DOI: 10.1177/0960327114564793

Abstract

Cyclophosphamide (CPA) chemotherapy leads to ovarian failure and infertility. Tocotrienol (T3) is an antioxidant and anti-inflammatory agent. The role of T3 in ovarian protection throughout chemotherapy remains unclear.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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