Introduction: Caregivers of children with speech-language pathology experience psychological distress as speech impedes communication and interferes children’s development. This study aimed to determine the effects of a one- day mindfulness-based intervention (MBI) in reducing depression, anxiety, and stress for caregivers of children with speech-language pathology in a Malaysian hospital. Methods: Caregivers (n = 62) who fulfilled the selection criteria were recruited and randomly assigned to either MBI or treatment-as-usual control groups. The caregivers completed self-rated questionnaires, namely the Depression Anxiety Stress Scale 21 (DASS 21) and Mindful Attention Aware- ness Scale (MAAS) before and at one-month post-intervention. Results: Hierarchical multiple regression analyses demonstrated significant improvement in DASS 21 and MAAS scores in the intervention group compared to control group. There were significant improvements at one-month post-intervention in all outcome measures: depression (β = 4.20, ΔR2 = 0.09, p = 0.008, f2 = 0.10); anxiety (β = 5.12, ΔR2 = 0.13, p = 0.001, f2 = 0.15); stress (β = 5.36, ΔR2 = 0.14, p