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Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia

Tan JL 1 , Simbun A 2 , Chan KG 3 , Ngeow YF 4

Affiliations 

  • 1 Faculty of Information Science and Technology, Multimedia University, Melaka, Malaysia
  • 2 Alfred Initiatives, 3 Elements SOHO, A-13-22 Taman Prima Tropica, 43300, Seri Kembangan, Selangor, Malaysia
  • 3 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Department of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Kajang, 43000, Selangor, DE, Malaysia. ngeowyf@utar.edu.my
Sci Data, 2020 05 05;7(1):135.
PMID: 32371951 DOI: 10.1038/s41597-020-0475-x

Abstract

Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes show mutations listed in current drug resistance databases and global MTB collections. This genome data will augment existing information available for comparative genomic studies to understand MTB drug resistance mechanisms and evolution.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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