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Screening of medicinal plants from Taman Herba Perlis for Acetylcholinesterase inhibitory activity

Abdul Somat N 1 , Osman CP 2 , Ismail NH 1 , Yusoff Z 3 , Md Yusof Y 3

Affiliations 

  • 1 Atta-ur-Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia
  • 2 1 Atta-ur-Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia 2Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia. Corresponding author: cheputeh@uitm.edu.my
  • 3 Faculty of Applied Sciences, University Teknologi MARA, Cawangan Perlis, Kampus Arau, 02600 Arau, Perlis, Malaysia
Science Letters, 2019;13(1):23-32.
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Abstract

In a search for new potential AChE inhibitors, 31 selected medicinal plants from Perlis were collected gathered, air dried and successively extracted using hexane, dichloromethane, and alcohol. The dichloromethane and alcoholic extracts were screened for AChE inhibitory activity using Ellman's method. Out of 31 plant species, the methanol extracts of Rhapis excelsa leaves (97.03 ± 3.71 %), Diospyros blancoi leaves (95.80 ± 1.57 %) and Phyllantus elegans root (83.22 ± 3.08 %) showed the highest AChE inhibitory activity at the concentration of 100 μg/mL.

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