Estimation of an Instrument-Defined Minimally Important Difference in EQ-5D-5L Index Scores Based on Scoring Algorithms Derived Using the EQ-VT Version 2 Valuation Protocols

Henry EB 1 , Barry LE 2 , Hobbins AP 3 , McClure NS 4 , O'Neill C 5

Affiliations 

  • 1 J.E. Cairnes School of Business and Economics, National University of Ireland Galway, Galway, Ireland
  • 2 Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland
  • 3 Centre for Research in Medical Devices and Health Economics and Policy Analysis Centre, National University of Ireland Galway, Galway, Ireland
  • 4 School of Public Health, University of Alberta, Edmonton, Alberta, Canada
  • 5 Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland. Electronic address: Ciaran.ONeill@qub.ac.uk
Value Health, 2020 07;23(7):936-944.
PMID: 32762996 DOI: 10.1016/j.jval.2020.03.003

Abstract

OBJECTIVES: To estimate and compare the minimally important difference (MID) in index score of country-specific EQ-5D-5L scoring algorithms developed using EuroQol Valuation Technology protocol version 2, including algorithms from Germany, Indonesia, Ireland, Malaysia, Poland, Portugal, Taiwan, and the United States.

METHODS: A simulation-based approach contingent on all single-level transitions defined by the EQ-5D-5L descriptive system was used to estimate the MID for each algorithm.

RESULTS: The resulting mean (and standard deviation) instrument-defined MID estimates were Germany, 0.083 (0.022); Indonesia, 0.093 (0.012); Ireland, 0.098 (0.023); Malaysia, 0.072 (0.010); Poland, 0.080 (0.030); Portugal, 0.080 (0.018); Taiwan, 0.101 (0.010); and the United States, 0.078 (0.014).

CONCLUSIONS: These population preference-based MID estimates and accompanying evidence of how such values vary as a function of baseline index score can be used to aid interpretation of index score change. The marked consistency in the relationship between the calculated MID estimate and the range of the EQ-5D-5L index score, represented by a ratio of 1:20, might substantiate a rule of thumb allowing for MID approximation in EQ-5D-5L index score warranting further investigation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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