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Evaluation of stem-like side population cells in a recurrent nasopharyngeal carcinoma cell line

Hoe SL 1 , Tan LP 2 , Jamal J 3 , Peh SC 4 , Ng CC 5 , Zhang WC 6 Show all authors , Ahmad M 2 , Khoo AS 2

Affiliations 

  • 1 Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia ; Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
  • 3 Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia ; Current address: Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Faculty of Medical Sciences, UCSI University, 1 Jalan Menara Gading, UCSI Heights, 56000 Cheras, Malaysia
  • 5 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 6 Genome Institute of Singapore, 60 Biopolis Street, #02-01, Genome, 138672 Singapore
Cancer Cell Int, 2014;14(1):101.
PMID: 25317078 DOI: 10.1186/s12935-014-0101-0

Abstract

Side population (SP) assay identifies cells with dye/drug extrusion ability, a characteristic of stem cells. Here, we determined if SP cells exist in a verified cell line originating from recurrent nasopharyngeal carcinoma (NPC) and a xenograft established from recurrent metastatic NPC. These cells were evaluated for stem-like properties via functional assays as well as for tumourigenicity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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