Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera: Cimicidae)

Dang K 1 , Toi CS 1 , Lilly DG 1 , Lee CY 2 , Naylor R 3 , Tawatsin A 4 Show all authors , Thavara U 4 , Bu W 5 , Doggett SL 1

Affiliations 

  • 1 Department of Medical Entomology, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia
  • 2 Urban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 3 Prior's Loft, Coleford Road, Tidenham, Monmouthshire, UK
  • 4 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand
  • 5 Institute of Entomology, College of Life Sciences, Nankai University, Tianjin, China
Pest Manag Sci, 2015 Jul;71(7):1015-20.
PMID: 25132449 DOI: 10.1002/ps.3880

Abstract

Bed bugs [both Cimex hemipterus (F.) and Cimex lectularius L.] are highly resistant to pyrethroids worldwide. An important resistance mechanism known as 'knockdown resistance' (kdr) is caused by genetic point mutations on the voltage-gated sodium channel (VGSC) gene. Previous studies have identified two point mutations (V419L and L925I) on the VGSC gene in C. lectularius that are responsible for kdr-type resistance. However, the kdr mutations in C. hemipterus have not been investigated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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