Introduction: Prevalence of musculoskeletal disorders (MSDs) among office workers found to be high worldwide, leading to considerable economic impacts and health issues. The relationship between MSDs and productivity loss is widely recognized. This study investigates the possible relationships between the self-reported musculoskeletal dis- orders and productivity in term of absenteeism/presenteeism and self-evaluated productivity levels during presentee- ism time among office workers. Methods: Cross-sectional study was carried among office workers (n=398) in three public sector organizations in Putrajaya. Socio-demographic and productivity data were determined using self-ad- ministered general questionnaire whereas prevalence of MSDs evaluated using Cornell Musculoskeletal Disorders Questionnaire (CMDQ). Results: This study found that prevalence of MSDs symptoms among office workers in any body parts is high (83.7%), low-back pain reported the highest (58.5%) whereas thighs pain reported less prevalent MSDs symptoms (25.4%) among participants. Also, the results showed a significant association between prevalence of MSDs and productivity loss in regard with presenteeism (p